Introducing PBSERUM — Professional bioremodeling enzymes, now available
pbserum Plus
pbserum PlusPlus
pbserum Plus Smooth+
Collagenase enzyme for scars, fibrosis, and skin tightening. Use in the Plus triad to target dense or mature tissue alongside Slim+ and Drain+.
Recombinant Collagenases G&H PB220 in a lyophilized format for customizable cocktail mixing. Smooth+ combines two collagenase variants: Collagenase G selectively degrades fragmented Type I collagen, while Collagenase H acts on a broader spectrum including Types I and III, providing comprehensive cleanup of damaged collagen scaffolding. This dual-collagenase action makes Smooth+ the tissue remodeling engine of the Plus cocktail system. By clearing fibrotic tissue, old scar collagen, and fragmented fibers, Smooth+ creates the biological conditions for new collagen synthesis — fibroblasts respond to the cleared environment by producing fresh, properly organized collagen matrix. Indicated for scars, fibrosis, skin tightening, and overall tissue quality improvement. When combined with Slim+ and Drain+ in custom ratios, the triple enzyme cocktail addresses fat, fluid, and fibrosis simultaneously. Each case of 10 vials (0.07g each) supports multiple treatment sessions with flexible dosing.
Pack: 10 powder vials (0.07g each)
Prices in US$. Volume pricing is based on the total quantity across your entire cart.
SKU: PBS-PLS-SMT·USD
All prices exclude tax.
pbserum Plus
Personalized recombinant enzyme solutions to achieve precise results. Three enzymes (Slim+, Drain+, Smooth+) mixed in custom ratios per indication. Effective, safe and versatile enzyme cocktail for facial and body treatments.
Also in this line
How It Works
Recombinant enzyme technology — precision molecular biology for skin renewal
Collagenase G & H
PB220Targets: Fragmented collagen Types I & III
Lab-engineered recombinant enzymes that act as precision molecular scissors. Collagenase G cleaves Type I collagen (fragmented scaffolding) while Collagenase H targets both Types I & III for broader cleanup. Together they clear damaged tissue and stimulate fibroblasts to produce fresh collagen.
Learn more about Collagenase G & H →Mechanism of Action
Enzyme Action
Precision-engineered enzymes target and break down damaged tissue components in the extracellular matrix.
Cellular Response
The cleared environment signals fibroblasts to activate, initiating collagen and elastin synthesis.
Tissue Renewal
New collagen and elastin fibers organize into a healthy, structured matrix with improved firmness and texture.
Bioremodeling Cascade
A three-phase protocol for complete skin restoration
Phase 1
Reset
Enzymes clear damaged, fragmented tissue — collagen debris, excess HA, fat deposits, matrix congestion. Creates a clean biological canvas.
Reveal, Plus, Hyal balance
Phase 2
Stimulation
The cleared environment responds optimally to active ingredients — growth factors, peptides, vitamins, antioxidants reach fibroblasts directly.
Specific, Veluria
Phase 3
Maintain
Home care supports regeneration with keratinase-enhanced penetration. New collagen and elastin fibers organize into healthy tissue.
Smartker
Treatment Protocol
Professional application guide
4-8 sessions, spaced 14 days apart, 45 minutes each.
Application Steps
- 1.
Cleanse treatment area thoroughly
- 2.
Select enzyme vials based on treatment indication
- 3.
Reconstitute and mix custom cocktail ratio per protocol
- 4.
Apply topically with targeted massage technique
- 5.
Leave on skin for recommended duration
What to Expect
Visible improvement typically begins after the first session and progresses with each treatment. The enzymatic bioremodeling cascade continues working between sessions — the 14-day interval allows the tissue to complete its natural regeneration cycle before the next application.
Indicated for: Face, Body, Scars, Fibrosis, Skin tightening, Stretch marks, Acne scars, Post surgical fibrosis, Keloids
Mixing Ratios
| Indication | Recipe |
|---|---|
| Scars and fibrosis | 2x Smooth+ : 1x Drain+ |
| Skin tightening | 1x Smooth+ : 1x Slim+ : 1x Drain+ |
| Surface irregularities | 2x Smooth+ : 1x Drain+ |
Composition
INCI- Mannitol
- Sodium Phosphate
- Disodium EDTA
- r-Clostridium Histolyticum Collagenase G
- r-Clostridium Histolyticum Collagenase H
What's in the Box
Enzyme Powder Vials
Lyophilized Collagenase G&H PB220 — 0.07g per vial
10x5 5/16 × 2 1/4 × 2 15/16 in • 0.36 lb
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